Papers
2020:
BIRTH SEASON AND INFECTION RISK AMONG CHILDREN UNDER 5 YEARS OLD: A STUDY OF HOSPITAL ADMISSIONS AND SHORT MESSAGE SERVICE-REPORTED SYMPTOMS AT HOME. Pediatr Infect Dis J. 2020 Jan;39(1):23-29
PHYSICAL ACTIVITY AND SPATIAL MEMORY ARE MINIMALLY AFFECTED BY MODERATE GROWTH RESTRICTION IN PRETERM PIGLETS. Dev Neurosci. 2020; 41(3-4):1-8
2019:
BOVINE COLOSTRUM AGAINST CHEMOTHERAPY-INDUCED GASTROINTESTINAL TOXICITY IN CHILDREN WITH ACUTE LYMPHOBLASTIC LEUKEMIA: A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL. JPEN J. 2019 Mar 12. doi: 10.1002/jpen.1528.
BOVINE MILK OLIGOSACCHARIDES WITH SIALYLLACTOSE IMPROVES COGNITION IN PRETERM PIGS. Nutrients. 2019;11(6).
EFFECT OF FECAL MICROBIOTA TRANSPLANTATION ROUTE OF ADMINISTRATION ON GUT COLONIZATION AND HOST RESPONSE IN PRETERM PIGS. ISME J. 2019;13(3):720-733
FORTICOLOS - A MULTICENTRE STUDY USING BOVINE COLOSTRUM AS A FORTIFIER TO HUMAN MILK IN VERY PRETERM INFANTS: STUDY PROTOCOL FOR A RANDOMISED CONTROLLED PILOT TRIAL. Trials. 2019;20(1):279
GUT AND IMMUNE EFFECTS OF BIOACTIVE MILK FACTORS IN PRETERM PIGS EXPOSED TO PRENATAL INFLAMMATION. Am J Physiol Gastrointest Liver Physiol. 2019 May 15. doi: 10.1152/ajpgi.00042.2019. [Epub ahead of print]
HUMAN MILK FORTIFICATION WITH BOVINE COLOSTRUM IS SUPERIOR TO FORMULA-BASED FORTIFIERS TO PREVENT GUT DYSFUNCTION, NECROTIZING ENTEROCOLITIS, AND SYSTEMIC INFECTION IN PRETERM PIGS. JPEN 2019;43(2):252-262
IMPACT OF EARLY EXPOSURE TO CEFUROXIME ON THE COMPOSITION OF THE GUT MICROBIOTA IN INFANTS FOLLOWING CESAREAN DELIVERY. J Pediatr. 2019;210:99-105.e2.
METABOLISM OF MILK OLIGOSACCHARIDES IN PRETERM PIGS SENSITIVE TO NECROTIZING ENTEROCOLITIS. Front Nutr. 2019;12;6:23.
MILK FEED OSMOLALITY AND ADVERSE EVENTS IN NEWBORN INFANTS AND ANIMALS: A SYSTEMATIC REVIEW. Arch Dis Child Fetal Neonatal Ed. 2019 May;104(3):F333-F340. doi: 10.1136/archdischild-2018-315946. Epub 2018 Dec 6.
NEW GENERATION LIPID EMULSIONS INCREASE BRAIN DHA AND IMPROVE BODY COMPOSITION, BUT NOT SHORT-TERM NEURODEVELOPMENT IN PARENTERALLY-FED PRETERM PIGLETS. Brain Behav Immun. 2019 Apr 24. pii: S0889-1591(19)30426-X. doi: 10.1016/j.bbi.2019.04.031. [Epub ahead of print]
ORAL SUPPLEMENTATION WITH BOVINE COLOSTRUM PREVENTS SEPTIC SHOCK AND BRAIN BARRIER DISRUPTION DURING BLOODSTREAM INFECTION IN PRETERM NEWBORN PIGS. 2019 Mar;51(3):337-347
PRETERM BIRTH HAS EFFECTS ON GUT COLONIZATION IN PIGLETS WITHIN THE FIRST 4 WEEKS OF LIFE. J Pediatr Gastroenterol Nutr. 2019;68(5):727-733
RAPID CEREBRAL METABOLIC SHIFT DURING NEONATAL SEPSIS IS ATTENUATED BY ENTERAL COLOSTRUM SUPPLEMENTATION IN PRETERM PIGS. Metabolites. 2019 Jan 11;9(1).
RAPID POSTNATAL ADAPTATION OF NEURODEVELOPMENT IN PIGS BORN LATE PRETERM. Dev Neurosci. 2018;40(5-6):586-600
SPECIFIC GUT MICROBIOME MEMBERS ARE ASSOCIATED WITH DISTINCT IMMUNE MARKERS IN PEDIATRIC ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION. Microbiome. 2019;7(1):131.
STAGING OF NECROTISING ENTEROCOLITIS BY BELL'S CRITERIA IS SUPPORTED BY A STATISTICAL PATTERN ANALYSIS OF CLINICAL AND RADIOLOGICAL VARIABLES. Acta Paediatr. 2019;108(5):842-848
STRUCTURAL BRAIN MATURATION DIFFERS BETWEEN PRETERM AND TERM PIGLETS, WHEREAS BRAIN ACTIVITY DOES NOT. Acta Paediatr. 2019;108(4):637-644.
SYNBIOTICS COMBINED WITH GLUTAMINE STIMULATE BRAIN DEVELOPMENT AND THE IMMUNE SYSTEM IN PRETERM PIG. J Nutr. 2019;149(1):36-45
TIME TO FULL ENTERAL FEEDING FOR VERY LOW BIRTH WEIGHT INFANTS VARIES MARKEDLY AMONG HOSPITALS WORLDWIDE BUT MAY NOT BE ASSOCIATED WITH INCIDENCE OF NECROTIZING ENTEROCOLITIS: THE NEOMUNE-NEONUTRINET COHORT STUDY. JPEN. 2019;43(5):658-667
2018:
ANIMAL MODELS OF CHEMOTHERAPY-INDUCED MUCOSITIS: TRANSLATIONAL RELEVANCE AND CHALLENGES. Am J Physiol Gastrointest Liver Physiol. 2018;314(2):G231-G246
ASSOCIATION BETWEEN MODE OF DELIVERY AND RISK OF INFECTION IN EARLY CHILDHOOD: A COHORT STUDY. Pediatr Infect Dis J. 2018;37(4):316-323.
A VIRUS INFECTION ALTERS GUT MICROBIOTA COMPOSITION IN JUVENILE MICE. J Inf DisTrav Med 2018; 2:000118.
BALANCING STANDARDISATION AND INDIVIDUAL TREATMENTS IN TRANSLATIONAL NEONATOLOGY RESEARCH. Biosocieties. 2018;13(2):349-367.
BIOACTIVE WHEY PROTEIN CONCENTRATE AND LACTOSE STIMULATE GUT FUNCTION IN FORMULA-FED PRETERM PIGS. J Pediatr Gastroenterol Nutr. 2018;66(1):128-134.
BOVINE COLOSTRUM FOR PRETERM INFANTS IN THE FIRST DAYS OF LIFE: A RANDOMIZED CONTROLLED PILOT TRIAL. J Pediatr Gastroenterol Nutr. 2018;66(3):471-478.
BOVINE MILK OLIGOSACCHARIDES WITH SIALYLLACTOSE FOR PRETERM PIGLETS. Nutrients. 2018;10(10)
BRAIN BARRIER DISRUPTION AND REGION-SPECIFIC NEURONAL DEGENERATION DURING NECROTIZING ENTEROCOLITIS IN PRETERM PIGS. Dev Neurosci. 2018;40(3):198-208
CHANGES IN GUT MICROBIOTA PRIOR TO INFLUENZA A VIRUS INFECTION DO NOT AFFECT IMMUNE RESPONSES IN PUPS OR JUVENILE MICE. Front Cell Infect Microbiol. 2018;8:319.
DIET-DEPENDENT CHANGES IN THE INTESTINAL DNA METHYLOME AFTER INTRODUCTION OF ENTERAL FEEDING IN PRETERM PIGS. Epigenomics. 2018;10(4):395-408.
EARLY MICROBIAL COLONIZATION AFFECTS DNA METHYLATION OF GENES RELATED TO INTESTINAL IMMUNITY AND METABOLISM IN PRETERM PIGS. DNA Res. 2018. doi: 10.1093/dnares/dsy001
HUMANITY AT THE EDGE: THE MORAL LABORATORY OF FEEDING PRECARIOUS LIVES. Cult Med Psychiatry. 2017;41(2):202-223
HUMAN MILK OLIGOSACCHARIDES TO PREVENT GUT DYSFUNCTION AND NECROTIZING ENTEROCOLITIS IN PRETERM NEONATES Nutrients 2018;10(10)
NECROTIZING ENTEROCOLITIS IS ASSOCIATED WITH ACUTE BRAIN RESPONSES IN PRETERM PIGS. J Neuroinflammation. 2018 ;15(1):180.
NEONATAL GUT AND IMMUNE MATURATION IS DETERMINED MORE BY POSTNATAL AGE THAN BY POST-CONCEPTIONAL AGE IN MODERATELY PRETERM PIGS. Am J Physiol Gastrointest Liver Physiol. 2018;315(5):G855-867
NUTRIENT FORTIFICATION OF HUMAN DONOR MILK AFFECTS INTESTINAL FUNCTION AND PROTEIN METABOLISM IN PRETERM PIGS. J Nutr. 2018;148(3):336-347
POSTNATAL ADMINISTRATION OF LACTOBACILLUS RHAMNOSUS HN001 AMELIORATES PERINATAL BROAD-SPECTRUM ANTIBIOTIC-INDUCED REDUCTION IN MYELOPOIESIS AND T CELL ACTIVATION IN MOUSE PUPS. Mol Nutr Food Res. 2018;62(22)
PRECISION MEDICINE FOR NEONATAL SEPSIS. Front Mol Biosci. 2018. 5:70 Review.
PRENATAL INTRA-AMNIOTIC ENDOTOXIN INDUCES FETAL GUT AND LUNG IMMUNE RESPONSES AND POSTNATAL SYSTEMIC INFLAMMATION IN PRETERM PIGS. Am J Pathol. 2018;188(11):2629-2643
TRANSLATIONAL NEONATOLOGY RESEARCH: TRANSFORMATIVE ENCOUNTERS ACROSS SPECIES AND DISCIPLINES. Hist Philos Life Sci. 2018;22;40(1):21.
TROPHIC FACTORS IN THE TREATMENT AND PREVENTION OF ALIMENTARY TRACT MUCOSITIS. Curr Opin Support Palliat Care. 2018 ;12(2):181-186.
2017:
ANTIBIOTIC TREATMENT PREVENTING NECROTISING ENTEROCOLITIS ALTERS URINARY AND PLASMA METABOLOMES IN PRETERM PIGS. J Proteome Res. 2017;16(10):3547-3557.
A STEPWISE, PILOT STUDY OF BOVINE COLOSTRUM TO SUPPLEMENT THE FIRST ENTERAL FEEDING IN PRETERM INFANTS (PRECOLOS): STUDY PROTOCOL AND INITIAL RESULTS. Front Pediatr. 2017;5:42.
CHEMOTHERAPEUTIC TREATMENT REDUCES CIRCULATING LEVELS OF SURFACTANT PROTEIN-D IN CHILDREN WITH ACUTE LYMPHOBLASTIC LEUKEMIA. Pediatr Blood Cancer. 2017;64(3)
ELEVATED LEVELS OF CIRCULATING CELL-FREE DNA AND NEUTROPHIL PROTEINS ARE ASSOCIATED WITH NEONATAL SEPSIS AND NECROTIZING ENTEROCOLITIS IN IMMATURE MICE, PIGS AND INFANTS. Innate Immun. 2017; 23(6):524-536.
FEEDING PREMATURE NEONATES: KINSHIP AND SPECIES IN TRANSLATIONAL NEONATOLOGY. Soc Sci Med. 2017 179:129-136.
GLUCAGON-LIKE PEPTIDE 2 STIMULATES POSTRESECTION INTESTINAL ADAPTATION IN PRETERM PIGS BY AFFECTING PROTEINS RELATED TO PROTEIN, CARBOHYDRATE, AND SULPHUR METABOLISM JPEN J Parenter Enteral Nutr. 2017;41(8):1293-1300
HUMAN MILK OLIGOSACCHARIDE EFFECTS ON INTESTINAL FUNCTION AND INFLAMMATION AFTER PRETERM BIRTH IN PIGS. J Nutr Biochem. 2017 40:141-154.
INCREASED INTESTINAL INFLAMMATION AND DIGESTIVE DYSFUNCTION IN PRETERM PIGS WITH SEVERE NECROTIZING ENTEROCOLITIS. Neonatology. 2017;111(4):289-296
INFANT RESPIRATORY TRACT INFECTIONS OR WHEEZE AND MATERNAL VITAMIN D IN PREGNANCY: A SYSTEMATIC REVIEW. Pediatr Infect Dis J 2017 36:384-391.
SUPPLEMENTATION WITH LACTOBACILLUS PARACASEI OR PEDIOCOCCUS PENTOSACEUS DOES NOT PREVENT DIARRHOEA IN NEONATAL PIGS INFECTED WITH ESCHERICHIA COLI F18. Br J Nutr. 2017 118(2):109-120.
SURGICAL FINDINGS DURING EXPORATORY LAPAROTOMY ARE CLOSELY RELATED TO MORTALITY IN PREMATURE INFANTS WITH NECROTIZING ENTEROCOLITIS. Acta Paediatr. 2017;106(3):399-404.
THE MICROBIAL COMMUNITY OF THE GUT DIFFERS BETWEEN PIGLETS FED SOW MILK, MILK REPLACER OR BOVINE COLOSTRUM. Br J Nutr. 2017;117(7):964-978.
2016:
BOVINE COLOSTRUM IMPROVES NEONATAL GROWTH, DIGESTIVE FUNCTION AND GUT IMMUNITY RELATIVE TO DONOR HUMAN MILK AND INFANT FORMULA IN PRETERM PIGS. Am J Physiol Gastrointest Liver Physiol. 2016;311(3):G480-91
BOVINE LACTOFERRIN REGULATES CELL SURVIVAL, APOPTOSIS AND INFLAMMATION IN INTESTINAL EPITHELIAL CELLS AND PRETERM PIG INTESTINE J Proteomics. 2016;139:95-102.
CHEMOTHERAPY MODULATES INTESTINAL IMMUNE GENE EXPRESSION INCLUDING SURFACTANT PROTEIN-D AND DELETED IN MALIGNANT BRAIN TUMORS 1 IN PIGLETS. Chemotherapy. 2016;61(4):204-16.
DELAYED DEVELOPMENT OF SYSTEMIC IMMUNITY IN PRETERM PIGS AS A MODEL FOR PRETERM INFANTS Sci Rep. 2016;6:36816.
DELAYED GROWTH, MOTOR FUNCTION AND LEARNING IN PRETERM PIGS DURING EARLY POSTNATAL LIFE. Am J Physiol Regul Integr Comp Physiol. 2016;310(6):R481-92.
DOXORUBICIN-INDUCED GUT TOXICITY IN PIGLETS FED BOVINE MILK AND COLOSTRUM J Pediatr Gastroenterol Nutr. 2016;63(6):698-707
EFFECT OF DONOR MILK ON SEVERE INFECTIONS AND MORTALITY IN VERY LOW-BIRTH-WEIGHT INFANTS: THE EARLY NUTRITION STUDY RANDOMIZED CLINICAL TRIAL. JAMA Pediatr. 2016;170(7):654-61.
ENTERAL BUT NOT PARENTERAL ANTIBIOTICS ENHANCE GUT FUNCTION AND PREVENT NECROTIZING ENTEROCOLITIS IN FORMULA-FED NEWBORN PRETERM PIGS. Am J Physiol 2016;310:G323-33.
LIMITED EFFECTS OF PRETERM BIRTH AND THE FIRST ENTERAL NUTRITION ON CEREBELLUM MORPHOLOGY AND GENE EXPRESSION IN PIGLETS Physiol Rep. 2016;4(14).
MILK DIETS INFLUENCE DOXORUBICIN-INDUCED INTESTINAL TOXICITY IN PIGLETS Am J Physiol Gastrointest Liver Physiol. 2016;311(2):G324-33.
NASOGASTRIC FEEDING TUBES FROM A NEONATAL DEPARTMENT YIELD HIGH CONCENTRATIONS OF POTENTIALLY PATHOGENIC BACTERIA- EVEN 1 D AFTER INSERTION. Pediatr Res. 2016;80(3):395-400.
ORAL ANTIBIOTICS INCREASE BLOOD NEUTROPHIL MATURATION AND REDUCE BACTEREMIA AND NECROTIZING ENTEROCOLITIS IN THE IMMEDIATE POSTNATAL PERIOD OF PRETERM PIGS. Innate Immun 2016;22:51-62
PHYSICAL ACTIVITY AND GASTRIC RESIDUALS AS BIOMARKERS FOR REGION-SPECIFIC NEC LESIONS IN PRETERM NEONATES Neonatology. 2016;110(4):241-247
PROBIOTICS TO PREVENT NECROTISING ENTEROCOLITIS IN VERY PRETERM INFANTS. Dan Med J. 2016;63(3).
PROCESSING OF WHEY MODULATES PROLIFERATIVE AND IMMUNE FUNCTIONS IN INTESTINAL EPITHELIAL CELLS. J Dairy Sci 2016;99:959-69
PROVISION OF AMNIOTIC FLUID DURING PARENTERAL NUTRITION INCREASES WEIGHT GAIN WITH LIMITED EFFECTS ON GUT STRUCTURE, FUNCTION, IMMUNITY, AND MICROBIOLOGY IN NEWBORN PRETERM PIGS. J Parenter Enteral Nutr. 2016;40(4):552-66.
RAPID GUT GROWTH BUT PERSISTENT DELAY IN DIGESTIVE FUNCTION IN THE POSTNATAL PERIOD OF PRETERM PIGS. Am J Physiol Gastrointest Liver Physiol. 2016;310(8):G550-60.
SPRAY DRIED, PASTEURISED BOVINE COLOSTRUM PROTECTS AGAINST GUT DYSFUNCTION AND INFLAMMATION IN PRETERM PIGS J Pediatr Gastroenterol Nutr. 2016;63(2):280-7
THE HALF-LIFE AND EXPOSURE OF CEFUROXIME VARIED IN NEWBORN INFANTS AFTER A CAESAREAN SECTION. Acta Paediatr. 2016;105(9):1074-8.
2015:
ASSOCIATIONS BETWEEN GASTROINTESTINAL TOXICITY, MICRO RNA AND CYTOKINE PRODUCTION IN PATIENTS UNDERGOING MYELOABLATIVE ALLOGENEIC STEM CELL TRANSPLANTATION. Int Immunopharmacol 2015;25:180-8
BOVINE COLOSTRUM MODULATES MYELOABLATIVE CHEMOTHERAPY–INDUCED GUT TOXICITY IN PIGLETS J Nutr. 2015;145(7):1472-80
DANSK FORSKNINGSCENTER VIL STYRKE PRÆMATURE BØRN MED OPTIMERET ERNÆRING Livsbladet 2015 15(2):10-16
DYNAMICS AND STABILIZATION OF THE HUMAN GUT MICROBIOME DURING THE FIRST YEAR OF LIFE Cell Host & Microbe 2015;17:690–703
EARLY GRADUAL FEEDING WITH BOVINE COLOSTRUM IMPROVES GUT FUNCTION AND NEC RESISTANCE RELATIVE TO INFANT FORMULA IN PRETERM PIGS Am J Physiol 2015;309:G310-23
EFFECT OF BOVINE COLOSTRUM FEEDING IN COMPARISON WITH MILK REPLACER AND NATURAL FEEDING ON THE IMMUNE RESPONSES AND COLONISATION OF ENTEROTOXIGENIC ESCHERICHIA COLI IN THE INTESTINAL TISSUE OF PIGLETS British Journal of Nutrition 2015;113:923–934
INTRODUCING ENTERAL FEEDING INDUCES INTESTINAL SUBCLINICAL INFLAMMATION AND RESPECTIVE CHROMATIN CHANGES IN PRETERM PIGS Epigenomics 2015;7:553-65
NECROTIZING ENTEROCOLITIS IN PRETERM PIGS IS ASSOCIATED WITH INCREASED DENSITY OF INTESTINAL MUCOSA-ASSOCIATED BACTERIA INCLUDING CLOSTRIDIUM PERFRINGENS Neonatology 2015;108:188-95
PHYSICAL ACTIVITY LEVEL IS IMPAIRED AND DIET DEPENDENT IN PRETERM NEWBORN PIGS Pediatr Res. 2015;78:137-44
PRETERM BIRTH REDUCES NUTRIENT ABSORPTION WITH LIMITED EFFECT ON IMMUNE GENE EXPRESSION AND GUT COLONIZATION IN PIGS J Pediatr Gastroenterol Nutr. 2015;61(4):481-90
PROTECTIVE EFFECTS OF TRANSFORMING GROWTH FACTOR Β2 IN INTESTINAL EPITHELIAL CELLS BY REGULATION OF PROTEINS ASSOCIATED WITH STRESS AND ENDOTOXIN RESPONSES PLoS One. 2015;10(2):e0117608
UNCHANGED INCIDENCE OF NEC OVER 13 YEARS AT RIGSHOSPITALET Dan Med J 2015;62:A5091
2014:
AMNIOTIC FLUID AND COLOSTRUM AS POTENTIAL DIETS IN THE CRITICAL CARE OF PRETERM INFANTS Diet and Nutrition in Critical Care, DOI 10.1007/978-1-4614-8503-2_131-1, Springer Science+Business Media New York 2014
ANIMAL MODELS OF GASTROINTESTINAL AND LIVER DISEASES. ANIMAL MODELS OF INFANT SHORT BOWEL SYNDROME: TRANSLATIONAL RELEVANCE AND CHALLENGES Am J Physiol Gastrointest Liver Physiol 2014;307:G1147–G1168
ANTIBIOTICS MODULATE INTESTINAL IMMUNITY AND PREVENT NECROTIZING ENTEROCOLITIS IN PRETERM NEONATAL PIGLETS Am J Physiol Gastrointest Liver Physiol 2014;306:G59–G71
BOVINE COLOSTRUM IMPROVES INTESTINAL FUNCTION FOLLOWING FORMULA-INDUCED GUT INFLAMMATION IN PRETERM PIGS Clin Nutr. 2014;33(2):322-9.
CLINICAL APPLICATIONS OF BOVINE COLOSTRUM THERAPY: A SYSTEMATIC REVIEW Nutr. Rev. 2014;72(4):237-54.
DUAL PURPOSE USE OF PRETERM PIGLETS AS A MODEL OF PEDIATRIC GI DISEASE Veterinary Immunology and Immunopathology 2014;159:156–165
INTESTINAL PROTEOMICS IN PIG MODELS OF NECROTIZING ENTEROCOLITIS, SHORT BOWEL SYNDROME AND INTRAUTERINE GROWTH RESTRICTION Proteomics Clin. Appl. 2014;8:700–714
MARKED METHYLATION CHANGES IN INTESTINAL GENES DURING THE PERINATAL PERIOD OF PRETERM NEONATES BMC Genomics 2014;15:716
MODULATION OF INTESTINAL INFLAMMATION BY MINIMAL ENTERAL NUTRITION WITH AMNIOTIC FLUID IN PRETERM PIGS J Parenter Enteral Nutr. 2014;38(5):576-86.
RAW BOVINE MILK IMPROVES GUT RESPONSES TO FEEDING RELATIVE TO INFANT FORMULA IN PRETERM PIGLETS Am J Physiol Gastrointest Liver Physiol. 2014;306(1):G81-90
TRANSFORMING GROWTH FACTOR-Β2 AND ENDOTOXIN INTERACT TO REGULATE HOMEOSTASIS VIA INTERLEUKIN-8 LEVELS IN THE IMMATURE INTESTINE Am J Physiol Gastrointest Liver Physiol. 2014;307(7):G689-99