Work package 1.1
Hypothesis: Caesarean birth affects the gut microbiota and infection resistance in infants.
Mode of delivery and gut microbiota
The mode of birth, Caesarean section or vaginal delivery, may exert long term influences on the infant gut microbiota and immunity (5). While previous studies have indicated differences, these have used relatively insensitive methods for microbiota analyses.
Methods
Fecal samples from infants and mothers at 0, 4 and at 12 months after birth (Vaginal delivery or Caesarean section) are frozen at -80oC.
Results
Metagenomic analyses (complete genome sequencing and SNPs for polymorphisms) will show how the infant gut microbiota is influenced by birth colonization, food patterns and antibiotics during the first year of life, and how this relates to maternal gut microbiota. Results are important as reference for other WP1 studies.
Synopsis
Publications
Leaders for WP 1.1
- Jovanna Dahlgren
- Karsten Kristiansen
- Wang Jung
Work package 1
WP 1.1
Caesarean birth affects the gut microbiota and infection resistance in infants
WP 1.2
Infant infection rates are associated with birth method, breast-feeding and antibiotics
WP 1.3
Infant health is improved by adding probiotics or milk bioactives to infant formula
WP 1.4
Human banked milk is superior to formula for growth/immunity in preterm infants
WP 1.5
Use of pro- or antibiotics improves feeding tolerance and health in preterm infants
WP 1.6
Early enteral feeding, with or without probiotics, supports preterm infant health
WP 1.7
Social, cultural and ethical values limit new dietary treatments for infants