Work package 2.4

Hypothesis: Addition of milk bioactives to formula stimulates immunity, gut and brain maturation

Milk bioactives to improve immunity and organ maturation

While specific milk components have long been hypothesized to have important immune effects, firm evidence for effects in newborns is not available. Using diet- and microbiota-sensitive preterm pigs, we investigate how milk formulas enriched with selected milk bioactives affect immune, gut and brain maturation.

Methods

As for WP 2.3, using 1-2 week feeding. The specific protocol and the nature and depth of sample analyses (immune, gut, brain endpoints) will vary according to the choice of dietary intervention. Responses in isolated cells will be added for selected interventions.