Work package 1.4
Hypothesis: Human banked milk is superior to formula for growth/immunity in preterm infants.
Human donor milk versus formula
Feeding human milk to infants, not able to breast-feed (e.g. preterm infants), remains a challenge. It is not clear if pasteurized human donor milk has effects similar to own mother´s milk or formula (29). The first human milk bank has just been established in the Netherlands. We hypothesize that feeding exclusive human milk during the first 10 days benefits infant growth, gut microbiota, immunity and brain function in preterm infants.
Methods
A double-blind randomized-controlled trial in Amsterdam. If own mother’s milk is not available in sufficient amounts, preterm infants will receive additional donor milk or infant formula.
Results
Primary endpoints: incidence of serious infections, NEC and death. Secondary endpoints: composition of fecal microbiota, time to full enteral feeding, days on parenteral nutrition, growth rate, bone density, Bayley Scores of Infant Development at 2 years.
Synopsis
Publications
Leaders for WP 1.4
- Johannes van Goudoever
Work package 1
WP 1.1
Caesarean birth affects the gut microbiota and infection resistance in infants
WP 1.2
Infant infection rates are associated with birth method, breast-feeding and antibiotics
WP 1.3
Infant health is improved by adding probiotics or milk bioactives to infant formula
WP 1.4
Human banked milk is superior to formula for growth/immunity in preterm infants
WP 1.5
Use of pro- or antibiotics improves feeding tolerance and health in preterm infants
WP 1.6
Early enteral feeding, with or without probiotics, supports preterm infant health
WP 1.7
Social, cultural and ethical values limit new dietary treatments for infants